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Improved Approach to Local Drug Delivery

In a number of situations, traditional systemic drug delivery (typically oral and intravenous) has clear shortcomings. Optimum treatment outcomes may depend on useful vasculature and effective tissue binding. Following systemic administration, drugs may not reach the target organ in sufficient concentrations, with adequate viability or with consistent diffusion. At the same time, drugs may harm healthy tissue or cause other side effects.

At Focal Medical, we’re overcoming these obstacles by taking established but otherwise limited therapies in revolutionary new directions. Using an electrical current, we can achieve active, localized drug delivery at higher concentrations than achievable by systemic administration. Iontophoresis can drive drug molecules into cells using non-blood pathways, ensuring even poorly vascularized organs and tissues receive drug therapy. Drug molecules arrive with preserved viability and at greater concentrations, with no or limited off-target effects.

Tapping electrical forces to deliver drugs

Our iontophoresis system uses electrical current to drive drug into cells. When current is applied to an electrode, the drug exits the device through a semi-permeable membrane and is actively carried into the target tissue by the electric field. Our technology co-ops non-blood pathways to transit tissue and penetrate cells and thus overcomes both limited delivery and drug degradation issues. By delivering the drug into the cellular matrix, the patient can tolerate the increased concentration of drug necessary to achieve a therapeutic effect.

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Focal Medical, Inc.
111 James Jackson Ave. Suite 131
Cary, NC 27513

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